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Vaccination for IDH-mutant tumors: A novel therapeutic approach applied to glioma
David A Reardon1, Michael Weller2
1Center for Neuro-Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, D2134, Boston, MA 02115-5450, USA.
Med (New York, N.Y.)
|May 19, 2022
Abstract:
In a recent Nature publication, Platten et al. describe the feasibility, safety, immunogenicity, and encouraging efficacy of a vaccine targeting the IDH1 R132H protein among newly diagnosed patients with IDH1-mutant glioma. These findings raise promising therapeutic ramifications for the spectrum of IDH1/2-driven tumors.
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