Trigger-Responsive Poly(β-amino ester) Hydrogels
Yanfeng Zhang1, Rui Wang2, Yuyan Hua2
1Department of Materials Science and Engineering and ‡Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Abstract:
Water-soluble, acrylate-terminated poly(β-amino esters) with built-in trigger-responsive domains were synthesized through Michael addition of trigger-responsive diacrylates and primary amines. They were used as macromolecular precursors for photoinitiated cross-linking reactions to prepare trigger-responsive hydrogels for protein encapsulation. The encapsulated proteins could be rapidly released upon external triggering.
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