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Ulcerative colitis in sickle cell disease.

S I Terry, A Rajendran, B Hanchard

    Journal of Clinical Gastroenterology
    |February 1, 1987
    PubMed
    Summary
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    Sickle cell disease patients have a higher risk of developing severe proctocolitis. This study describes four such cases, highlighting a prevalence of three per 1,000 patients in sickle cell clinics.

    Area of Science:

    • Gastroenterology
    • Hematology
    • Clinical Medicine

    Background:

    • Sickle cell disease (SCD) is a genetic blood disorder.
    • Proctocolitis is inflammation of the rectum and colon.
    • A potential link between SCD and proctocolitis has been observed.

    Purpose of the Study:

    • To describe cases of severe proctocolitis in patients with homozygous sickle cell disease.
    • To investigate the prevalence of proctocolitis within a sickle cell disease patient cohort.
    • To explore potential reasons for an increased predisposition.

    Main Methods:

    • Case series description of four patients with homozygous SCD and severe proctocolitis.
    • Prevalence calculation based on patient data from a sickle cell clinic.

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  • Clinical observation and follow-up to identify contributing factors.

    • Main Results:

    • Four cases of severe proctocolitis in homozygous sickle cell disease patients were identified.
    • The prevalence of proctocolitis in this cohort was found to be three per 1,000 patients.
    • The underlying reasons for this predisposition were not definitively determined.

    Conclusions:

    • Homozygous sickle cell disease may be associated with an increased risk of severe proctocolitis.
    • Further research is needed to elucidate the mechanisms behind this association.
    • Clinical awareness and monitoring for proctocolitis in SCD patients are warranted.