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Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studies
Jacek J Jóźwiak1, Sławomir Kasperczyk2, Tomasz Tomasik3
1Department of Family Medicine and Public Health, Faculty of Medicine, University of Opole, Opole, Poland.
Archives of Medical Science : AMS
|May 20, 2022
Summary
This study investigated cardiovascular disease risk factors in Poland, focusing on lipid disorders, oxidative stress, and genetic predispositions. Findings highlight the prevalence of these factors and their links to cardiometabolic diseases.
Area of Science:
- Cardiology
- Genetics
- Biochemistry
Background:
- Cardiovascular disease (CVD) is a leading global cause of death.
- Atherosclerotic diseases share common risk factors with CVD.
- Understanding these factors in primary care is crucial for public health.
Purpose of the Study:
- To estimate the prevalence of atherosclerotic disease risk factors in Polish primary care.
- To analyze lipid metabolism, oxidative stress, and inflammatory markers.
- To identify genetic variants associated with cardiometabolic and atherosclerotic diseases.
Main Methods:
- Recruitment of 13,000-14,000 patients by 438 primary care physicians in Poland.
- Collection of questionnaire data on medical history, family history, and pharmacotherapy.
- Analysis of saliva for DNA and blood for biochemical markers (lipids, oxidative stress, inflammation, apolipoproteins).
Main Results:
- The study cohort reflects the prevalence of cardiovascular risk factors and related diseases.
- Data includes markers of oxidative stress, autoantibodies, inflammatory cytokines, and apolipoprotein profiles.
- Genetic variants conferring susceptibility to cardiometabolic and atherosclerotic diseases were assessed.
Conclusions:
- The study presents the prevalence of various cardiovascular risk factors, particularly lipid disorders.
- It assesses the interplay between inflammation, oxidative stress, and gene mutations in lipid metabolism.
- Findings contribute to understanding susceptibility to cardiovascular and cardiometabolic diseases.
