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Related Experiment Videos

Skin permeability in the newborn.

N Barker, J Hadgraft, N Rutter

    The Journal of Investigative Dermatology
    |April 1, 1987
    PubMed
    Summary

    Newborn infant skin is highly permeable to drugs, especially in preterm infants. This increased skin permeability in premature infants poses risks for accidental poisoning and offers potential for therapeutic drug administration.

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    Area of Science:

    • Neonatal dermatology
    • Pharmacokinetics
    • Drug absorption

    Background:

    • Neonatal skin exhibits unique properties influencing drug absorption.
    • Understanding drug permeability is crucial for safe neonatal care.

    Purpose of the Study:

    • To assess in vitro skin permeability to drugs in newborn infants.
    • To evaluate the impact of gestational age on drug absorption through neonatal skin.

    Main Methods:

    • Utilized an in vitro Franz-type diffusion cell system.
    • Measured the permeability of excised infant skin samples to sodium salicylate.

    Main Results:

    • Gestational age significantly impacts salicylate absorption.
    • Absorption was 100-1000 times greater in infants ≤30 weeks gestation compared to term infants.
    • Demonstrated significantly higher skin permeability in preterm infants.

    Conclusions:

    • Preterm infant skin exhibits markedly increased permeability.
    • High permeability necessitates caution to prevent accidental poisoning from topical agents.
    • The percutaneous route presents a viable alternative for therapeutic drug delivery in neonates.

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