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Updated: Sep 22, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Exploiting Electrostatic Interactions in Polymer-Nanoparticle Hydrogels.

Eric A Appel¹, Mark W Tibbitt¹, Jessica M Greer¹

¹David H. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, and Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

ACS Macro Letters

|May 21, 2022

Summary

This summary is machine-generated.

Researchers developed shear-thinning injectable hydrogels using polymer-nanoparticle interactions. These easily prepared hydrogels exhibit self-healing properties, making them suitable for biomedical applications.

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Area of Science:

Materials Science
Biomedical Engineering
Polymer Chemistry

Background:

Injectable hydrogels are crucial for minimally invasive biomedical applications.
Shear-thinning and self-healing properties are desirable for hydrogel deployment and function.
Current methods often require complex chemical modifications.

Purpose of the Study:

To engineer polymer-nanoparticle (PNP) interactions for self-assembled hydrogels.
To achieve shear-thinning and self-healing properties using electrostatic forces.
To fabricate PNP hydrogels from common biopolymers without chemical modification.

Main Methods:

Utilized electrostatic interactions between negatively charged biopolymers (hyaluronic acid, carboxymethylcellulose) and biodegradable nanoparticles (PEG-PLA).
Employed a positively charged surfactant (CTAB) to enhance polymer adsorption.
Characterized the viscoelastic properties of the fabricated PNP hydrogels.

Main Results:

Successfully fabricated PNP hydrogels with shear-thinning and self-healing capabilities.
Demonstrated the effectiveness of electrostatic interactions in hydrogel formation.
Showcased facile preparation and processing of hydrogels using common biopolymers.

Conclusions:

Developed a novel method for creating shear-thinning, self-healing PNP hydrogels.
Highlighted the potential of electrostatic interactions for tunable hydrogel properties.
Presented a versatile platform for biomedical and industrial applications requiring easily processed hydrogels.