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Updated: Sep 22, 2025
12:18
LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles
Published on: February 1, 2020
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The differential expression of long interspersed nuclear elements-1 as a marker for hypomethylation in Merkel cell
Yuko Kuriyama1, Akira Shimizu1,2, Jain Kim1
1Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan.
Clinical and Experimental Dermatology
|May 21, 2022
Abstract:
The protein long interspersed nuclear elements-1 (LINE-1) serves as a useful surrogate marker of global methylation but little is known for Merkel cell carcinoma. LINE-1 expression was found only in Merkel cell polyomavirus (MCPyV)-positive Merkel cell carcinomas but not in MCPyV-negative Merkel cell carcinomas, suggesting that epigenetic dysregulation may be associated with MCPyV expression.
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