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HPV29-Associated Periungual Epidermoid/Verrucous Cyst.
Sawako Ochiai1, Kazushi Anzawa1, Yuka Hiramatsu2
1Department of Dermatology, Kanazawa Medical University, Kahoku-gun, Ishikawa, Japan.
The Journal of Dermatology
|July 10, 2026
Summary
This study details a rare case of a human papillomavirus (HPV) type 29-associated periungual epidermoid/verrucous cyst. It is the first report of an HPV29-caused cyst and demonstrates active HPV29 infection.
Area of Science:
- Dermatology
- Virology
- Pathology
Background:
- Human papillomavirus (HPV) infections are linked to epidermoid cysts in hairless skin.
- HPV60 is the most common type found in these cysts.
- Epidermoid cysts are characterized by HPV DNA within the cyst epithelium.
Purpose of the Study:
- To report a rare case of an HPV29-associated periungual epidermoid/verrucous cyst.
- To demonstrate transcriptionally active HPV29 infection in a cutaneous lesion.
Main Methods:
- Histopathological examination of a periungual lesion.
- Polymerase chain reaction and direct sequencing for HPV DNA identification.
- RNA in situ hybridization to detect HPV29 E6/E7 mRNA.
Main Results:
- A rare HPV29-associated epidermoid/verrucous cyst was identified in a periungual location.
- HPV29 DNA was detected in formalin-fixed paraffin-embedded tissue.
- Transcriptionally active HPV29 infection was confirmed by RNA in situ hybridization.
Conclusions:
- This is the first reported case of an epidermoid/verrucous cyst caused by HPV29.
- The findings demonstrate the first evidence of transcriptionally active HPV29 infection in a cutaneous cyst.
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