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Connecting the dots: understanding how human mobility shapes TB epidemics
Tyler S Brown1, D Ashley Robinson2, Caroline O Buckee3
1Center for Communicable Disease Dynamics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Infectious Diseases Division, Massachusetts General Hospital, Boston, MA, USA.
Trends in Microbiology
|May 21, 2022
Summary
Human mobility significantly impacts tuberculosis (TB) transmission dynamics and the spread of Mycobacterium tuberculosis (Mtb) strains. Understanding these patterns is crucial for controlling TB epidemics and drug-resistant strains globally.
Area of Science:
- Epidemiology
- Infectious Disease Dynamics
- Public Health
Background:
- Tuberculosis (TB) is a major global infectious cause of mortality.
- Controlling TB transmission requires understanding how human movement influences Mycobacterium tuberculosis (Mtb) spread.
- Key questions persist regarding the role of mobility scales and patterns in TB transmission and the dispersal of drug-resistant strains.
Purpose of the Study:
- To review the current knowledge on human mobility and its impact on TB epidemic dynamics.
- To examine scientific questions and methodological challenges in understanding mobility's role in TB.
- To explore novel data sources for measuring human mobility in TB epidemiology.
Main Methods:
- Review of existing literature on human mobility and TB transmission.
- Analysis of examples from genetic/spatial clustering, source-sink dynamics, and strain dispersal.
- Evaluation of new mobility data sources, such as mobile phone data.
Main Results:
- Human mobility patterns are critical determinants of TB transmission and strain dispersal.
- Mobility influences the spread of both existing and emergent drug-resistant Mtb strains.
- Novel data sources offer potential but have limitations for epidemiological use.
Conclusions:
- Understanding human mobility is essential for effective TB control strategies.
- Further research is needed to refine methods for incorporating mobility data into TB epidemiology.
- Addressing mobility patterns can help mitigate the global burden of TB and drug-resistant TB.
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