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Updated: Sep 22, 2025

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
Published on: July 1, 2018
Oscillation-coordinated, noise-resistant information distribution via the subiculum
Kenji Mizuseki1, Takuma Kitanishi2
1Department of Physiology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Osaka 545-8585, Japan; Department of Physiology, Graduate School of Medicine, Osaka City University, Osaka, Osaka 545-8585, Japan.
Abstract:
The hippocampus processes information associated with spatial navigation. The subiculum receives input from the hippocampus CA1 and projects to various cortical and subcortical regions. Thus, the subiculum is uniquely positioned to distribute hippocampal information to a range of brain areas. Subicular neurons fire at higher rates than CA1 neurons and exhibit similarly or more accurately decodable representations of place, speed, and trajectory. These representations are more noise-resistant and advantageous for long-range information transfer. Subicular neurons selectively or uniformly distribute information to target areas, depending on the information type. Theta oscillations and sharp-wave ripples control information broadcasting in a pathway-specific manner. Thus, the subiculum routes accurately decodable, noise-resistant, navigation-associated information to downstream regions.
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