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Related Experiment Video

Updated: Sep 22, 2025

Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle VLP-Based Vaccines Using a Capture Assay

Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle VLP-Based Vaccines Using a Capture Assay

Published on: February 10, 2022

Protective neutralizing epitopes in SARS-CoV-2.

Hejun Liu¹, Ian A Wilson^1,2

¹Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.

Immunological Reviews

|May 22, 2022

Summary

This summary is machine-generated.

The COVID-19 virus (SARS-CoV-2) evolves to evade immunity, but vaccines and infections still offer protection against severe disease. Understanding antibody targets is key for new vaccines and treatments.

Keywords:

SARS-CoV-2 antibody coronavirus epitope vaccine variants

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Published on: March 24, 2017

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Last Updated: Sep 22, 2025

Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle VLP-Based Vaccines Using a Capture Assay

Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle VLP-Based Vaccines Using a Capture Assay

Published on: February 10, 2022

Engineering Antiviral Agents via Surface Plasmon Resonance

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Published on: June 14, 2022

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope

Published on: March 24, 2017

Area of Science:

Virology
Immunology
Epidemiology

Background:

The COVID-19 pandemic, caused by SARS-CoV-2, presents a global health and economic challenge.
SARS-CoV-2 has evolved increased transmissibility and immune evasion capabilities.
Despite viral evolution, infection and vaccination elicit protective immune responses against severe disease.

Purpose of the Study:

To review the mechanisms of SARS-CoV-2 host cell entry.
To summarize the host immune defense against SARS-CoV-2 infection.
To highlight the role of neutralizing antibodies in combating SARS-CoV-2 and its variants.

Main Methods:

Review of current scientific literature on SARS-CoV-2.
Analysis of host-pathogen interactions.
Examination of neutralizing antibody structures and epitopes.

Main Results:

SARS-CoV-2 utilizes specific mechanisms for host cell entry.
The immune system mounts defenses, including neutralizing antibodies, against the virus.
Antibody structures reveal protective epitopes targeted against ancestral and variant SARS-CoV-2 strains.

Conclusions:

Understanding SARS-CoV-2 entry and immune response is crucial.
Neutralizing antibodies are vital for protection against SARS-CoV-2 variants.
Epitope mapping informs the development of next-generation vaccines and antibody therapies.