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Ocular adnexal lymphoma: A single-institution retrospective study
César A Fernández1, Roger K Henry1,2, Carol L Shields3
1Department of Pathology, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA.
Summary
This study characterized ocular adnexal lymphoma (OAL), finding Extranodal Marginal Zone B-Cell Lymphoma (EMZL) in older females. Early recurrence was linked to excision with cryotherapy alone.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Ocular adnexal lymphoma (OAL) is a rare malignancy affecting the tissues around the eye.
- Understanding the specific characteristics of OAL is crucial for effective diagnosis and treatment planning.
Purpose of the Study:
- To comprehensively characterize the demographic, clinical, and histopathologic features of ocular adnexal lymphoma (OAL).
- To identify common subtypes, affected sites, and treatment outcomes in a large single-center cohort.
Main Methods:
- Retrospective review of 133 patients diagnosed with OAL between 2015 and 2020.
- Analysis of patient demographics, tumor histology, Ann-Arbor stage, treatment modalities, and recurrence patterns.
Main Results:
- The majority of OAL cases (99%) were non-Hodgkin B-cell lymphomas, predominantly Extranodal Marginal Zone B-Cell Lymphoma (EMZL, 70%).
- The orbit (64%) and conjunctiva (32%) were the most frequently involved sites.
- Recurrence was observed in 13% of patients, with earlier recurrence associated with excision and cryotherapy as the sole treatment (P = 0.003).
Conclusions:
- OAL predominantly affects older females and is most commonly Ann-Arbor Stage IE EMZL.
- Treatment with excision and cryotherapy alone may be associated with a higher risk of early recurrence.
