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Updated: Sep 22, 2025

Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses
Published on: September 11, 2023
A comprehensive review of biopsy techniques for oculoplastic and orbital surgeons from ophthalmic pathologists'
Hind M Alkatan1,2,3, Nada A Alyousef4, Norah S Alshabib4
1Department of Ophthalmology, King Saud University, Riyadh, Saudi Arabia.
Abstract:
This narrative review aims to discuss different modalities for obtaining diagnostic orbital biopsies, compares the available updated methods, and provides recommendations on the choice of technique. It also highlights special precautions in the handling of orbital specimens from various pathologies. A search was performed in PubMed and Google Scholar with no language or study type restriction. The keywords orbital biopsy, core biopsy, fine-needle aspiration biopsy, and orbit were used, and titles and abstracts were screened for relevance.
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