Nausea, Vomiting, and Dyspepsia Following Solid Organ Abdominal Transplant

Area of Science:

• Gastroenterology
• Transplant Surgery
• Clinical Medicine

Background:

• Post-transplant readmissions are a significant concern, potentially linked to comorbidities.
• Dyspeptic symptoms are common reasons for readmission in transplant recipients.

Purpose of the Study:

• To determine the rates of hospital readmissions for dyspeptic symptoms in solid organ transplant patients.
• To identify factors associated with 30-day and frequent readmissions post-transplant.

Main Methods:

• Retrospective analysis of adult solid organ transplant recipients.
• Inclusion of readmissions coded for dyspeptic symptoms (nausea, vomiting, abdominal pain, etc.).
• Exploration of factors including pre-transplant diabetes, post-transplant gastroparesis, and medication use.

Main Results:

• 30% of 931 transplant patients were readmitted within 30 days; 32.3% had frequent readmissions.
• Gastroparesis, suggested by EGD findings and confirmed by gastric emptying studies, was linked to higher readmission odds.
• Pre-transplant diabetes was associated with gastroparesis; belatacept use correlated with decreased 30-day readmissions.

Conclusions:

• Dyspeptic symptoms contribute to a substantial readmission rate after solid organ transplantation.
• Gastroparesis and diabetes are key risk factors for readmission, necessitating targeted management.
• Belatacept may play a protective role in reducing early readmissions.