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Consensus statement for treatment protocols in pressurized intraperitoneal aerosol chemotherapy (PIPAC).
Olivia Sgarbura1,2, Clarisse Eveno3, Mohammad Alyami4
1Department of Surgical Oncology, Cancer Institute of Montpellier, University of Montpellier, Montpellier, France.
Experts reached consensus on Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) drug regimens for peritoneal disease. Key research priorities include PIPAC conditions, standard and alternative regimens, and treatment efficacy.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) offers a novel approach for treating peritoneal disease.
- Standardization of PIPAC protocols is crucial for safe implementation and evaluation of new drug regimens.
- Expert consensus is needed to define current PIPAC treatment standards and future research directions.
Purpose of the Study:
- To achieve expert consensus on established Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) treatment protocols.
- To identify and prioritize critical research questions in the field of PIPAC therapy.
- To reduce heterogeneity in PIPAC treatment across different centers.
Main Methods:
- A hybrid consensus meeting with an expert panel from leading PIPAC centers was conducted.
- A modified three-round Delphi process was employed to reach consensus.
- Consensus was defined as 70% agreement, with research questions prioritized on a 0-10 scale.
Main Results:
- Consensus was achieved on all 10 final questions, with 22 experts participating.
- Doxorubicin and cisplatin combination was endorsed by 90.9% of experts.
- Oxaliplatin regimens and PIPAC-Ox with 5-FU received significant support, with Mitomycin-C and Nab-paclitaxel favored as alternatives.
Conclusions:
- The established consensus provides a framework to minimize variability in PIPAC treatment protocols.
- Further research is essential to advance the efficacy and application of PIPAC therapy.
- Prioritized research areas include PIPAC conditions, standard/alternative regimens, and treatment effectiveness.
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