Related Experiment Video
Updated: Sep 22, 2025
Purification of the Cystic Fibrosis Transmembrane Conductance Regulator Protein Expressed in Saccharomyces cerevisiae
Published on: May 10, 2014
Pollock: fishing for cell states
Erik P Storrs1,2, Daniel Cui Zhou1,2, Michael C Wendl1,2
1Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Motivation:
The use of single-cell methods is expanding at an ever-increasing rate. While there are established algorithms that address cell classification, they are limited in terms of cross platform compatibility, reliance on the availability of a reference dataset and classification interpretability. Here, we introduce Pollock, a suite of algorithms for cell type identification that is compatible with popular single-cell methods and analysis platforms, provides a set of pretrained human cancer reference models, and reports interpretability scores that identify the genes that drive cell type classifications.
Results:
Pollock performs comparably to existing classification methods, while offering easily deployable pretrained classification models across a wide variety of tissue and data types. Additionally, it demonstrates utility in immune pan-cancer analysis.
Availability And Implementation:
Source code and documentation are available at https://github.com/ding-lab/pollock. Pretrained models and datasets are available for download at https://zenodo.org/record/5895221.
Supplementary Information:
Supplementary data are available at Bioinformatics Advances online.
