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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
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Metabolic syndrome is associated with increased cardiovascular risk and disease damage in patients with Takayasu

Burçin Sağlam1, Sema Kaymaz-Tahra2, Gökçe Kenar3

  • 1Koc University School of Medicine, Rheumatology, Istanbul, Turkey.

International Journal of Rheumatic Diseases
|May 23, 2022
PubMed

Insights

Metabolic syndrome (MetS) significantly increases cardiovascular disease (CVD) risk and organ damage in Takayasu arteritis (TAK) patients. Managing MetS is crucial for improving outcomes in TAK.

Area of Science:

  • Rheumatology
  • Cardiology
  • Metabolic Diseases

Background:

  • Metabolic syndrome (MetS) is a known risk factor for cardiovascular disease (CVD).
  • Takayasu arteritis (TAK) is a large-vessel vasculitis that can lead to significant morbidity and mortality, often due to CVD.
  • The relationship between MetS and CVD/organ damage in TAK patients requires further investigation.

Purpose of the Study:

  • To determine the impact of Metabolic Syndrome (MetS) on the development of cardiovascular disease (CVD) and cumulative organ damage.
  • To analyze the association between MetS and clinical outcomes in a large cohort of Takayasu arteritis (TAK) patients.

Main Methods:

  • A cross-sectional study was conducted with 192 consecutive Takayasu arteritis (TAK) patients from seven Turkish rheumatology centers.
  • Data on cardiovascular disease (CVD) risk factors, disease activity, organ damage, and Metabolic Syndrome (MetS) were collected from medical records.
  • Patients met the 1990 American College of Rheumatology classification criteria for TAK.

Main Results:

  • Metabolic Syndrome (MetS) was present in 26% of the 192 Takayasu arteritis (TAK) patients.
  • MetS was identified as an independent risk factor for cardiovascular disease (CVD) (P < 0.001).
  • Patients with MetS exhibited a significantly higher mean vasculitis damage index compared to those without MetS (4.5 ± 3.3 vs. 3.2 ± 2.2, P = 0.004).

Conclusions:

  • Metabolic Syndrome (MetS) is significantly associated with increased cardiovascular disease (CVD) and cumulative organ damage in Takayasu arteritis (TAK) patients.
  • Early detection and effective management of MetS are essential for improving the prognosis of TAK.
  • This study highlights the importance of addressing metabolic health in the comprehensive care of TAK patients.
Abstract

Keywords:
Takayasu arteritiscardiovascular diseasemetabolic syndromevasculitis

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