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Updated: Sep 22, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Deoxygenative gem-difluorovinylation of aliphatic alcohols
Guang-Da Xia1, Yuan-Yuan He1, Jing Zhang1
1Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education & Hubei Key Laboratory of Catalysis and Materials Science, School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, China. hxq071303127@126.com.
Abstract:
An unprecedented deoxygenative gem-difluorovinylation of aliphatic alcohols using α-trifluoromethyl alkenes is achieved under photocatalytic conditions. Inexpensive Ph3P acts as an efficient O-atom transfer reagent to facilitate the deoxygenation of alcohols for the generation of reactive alkyl radical species. Remarkable features of this reaction include mild conditions, simple operation and broad scope. The synthetic utility of this reaction was validated by the success of two-step one-pot reactions, scale-up synthesis and chemoselective monodeoxygenation of diols.
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