Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

108
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
108
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

64
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
64
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

89
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
89
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

73
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
73
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

52
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
52
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

81
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
81

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Lived Experience of Individuals With Prosthetic Joint Infection.

Orthopedic nursing·2025
Same author

Advance Care Planning Completion and Decision-Making Among Older Adults With Cancer and Their Family Caregivers: Findings From a Mixed Methods Study.

The American journal of hospice & palliative care·2025
Same author

What Are the Predictors of Acute Care Nurses' Stroke Knowledge?: Empirical Research Quantitative.

Nursing open·2024
Same author

The Use of the Acute Stroke Management Questionnaire to Measure Acute Care Nurses' Stroke Knowledge.

The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses·2024
Same author

Health Screening Among a Rural, Hourly Workforce: North Carolina SERVIRE Project.

American journal of preventive medicine·2023
Same author

Exploring Cytokine Networks in Resistant Hypertension.

Nursing research·2023

Related Experiment Video

Updated: Sep 22, 2025

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice
02:45

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Published on: February 2, 2024

1.9K

Perioperative Urinary TIMP-2*IGFBP7 and Acute Kidney Injury: A Systematic Review.

Angela M Ciuca1, Linda P Bolin2, Carolyn Horne3

  • 1is a second-year nursing science PhD student at East Carolina University. She is also a faculty member of East Carolina University, Greenville, North Carolina in the nurse anesthesia program.

AANA Journal
|May 23, 2022
PubMed
Summary

Novel biomarkers urinary tissue inhibitor of metalloproteinase-2 * insulin-like growth factor binding protein 7 (uTIMP-2*IGFBP7) show high sensitivity for early detection of acute kidney injury (AKI) in surgical patients. Further research is needed to establish optimal measurement timing and cut-off values.

Keywords:
AKIAcute kidney injuryanesthesiologysurgicaluTIMP-2*IGFBP7urinary tissue inhibitor of metalloproteinase-2*insulin-like growth factor binding protein 7

More Related Videos

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.4K
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.6K

Related Experiment Videos

Last Updated: Sep 22, 2025

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice
02:45

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Published on: February 2, 2024

1.9K
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.4K
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.6K

Area of Science:

  • Nephrology
  • Surgical Critical Care
  • Biomarker Discovery

Background:

  • Acute kidney injury (AKI) is a frequent complication following major surgery.
  • Early identification of perioperative AKI is crucial for patient outcomes.
  • Limited research exists on intraoperative AKI detection in adult surgical patients.

Purpose of the Study:

  • To review and synthesize current literature on the utility of urinary tissue inhibitor of metalloproteinase-2 * insulin-like growth factor binding protein 7 (uTIMP-2*IGFBP7) for early AKI detection.
  • To evaluate the effectiveness of uTIMP-2*IGFBP7 in identifying perioperative AKI in adult surgical patients.

Main Methods:

  • Systematic literature search across CINAHL, ProQuest, Scopus, and PubMed databases.
  • PRISMA guideline adherence for literature review.
  • Synthesis of data from twelve selected articles.

Main Results:

  • The majority of reviewed studies indicate high sensitivity (AUROC >0.8) for uTIMP-2*IGFBP7 in detecting surgical-associated AKI.
  • Evidence suggests uTIMP-2*IGFBP7 can facilitate early identification of AKI during the perioperative period.

Conclusions:

  • uTIMP-2*IGFBP7 demonstrates significant potential as a sensitive biomarker for early perioperative AKI detection in major surgery.
  • Consensus is lacking on the optimal timing for uTIMP-2*IGFBP7 measurement and established cut-off values for AKI diagnosis.