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Updated: Sep 22, 2025

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Nitrogen-Centered Nucleophile Catalyzed Thiol-Vinylsulfone Addition, Another Thiol-ene "Click" Reaction
Weixian Xi1, Chen Wang2, Christopher J Kloxin3
1Department of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado 80309-0424, United States.
Abstract:
A new group of nitrogen-centered nucleophilic catalysts for the thiol-Michael addition "click" reactions is examined. These nucleophiles showed efficient catalytic activities as compared with traditional base catalysts, such as triethylamine, and are demonstrated to be a viable strategy for cross-linking polymerization reactions. Additionally, an experimental and computational mechanistic study was performed, suggesting a pathway for the nitrogen-centered catalyst to undergo the nucleophilic addition mechanism.
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