One-Pot Cascade Synthetic Strategy: A Smart Combination of Chemoenzymatic Transesterification and Raft Polymerization

Enzymatic transesterification was combined with RAFT polymerization to develop a new one-pot synthetic method for new polymer synthesis. This method contained in situ monomer transformation reaction between acyl donor monomer and primary alcohols such as hexanol and so on, followed by subsequent RAFT polymerization to get target polymers. The enzymatic reaction and RAFT polymerization tolerated each other and cooperated well to get new polymers with a completely transformed new monomer, high polymer yields, excellent control over the polymerization process, and good enzyme activity maintenance, providing a general and straightforward methodology for new polymer synthesis and modification.