Related Experiment Video
Updated: Sep 22, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
Published on: January 10, 2025
Abstract:
Retraction: "LINC00657 activates PD-L1 to promote osteosarcoma metastasis via miR-106a", by Jun Zhang, Xubin Chou, Ming Zhuang, Chenlei Zhu, Yong Hu, Dong Cheng, and Zhiwei Liu, J Cell Biochem. 2020; 4188-4195: The above article, published online on 3 January 2020 in Wiley Online Library (doi:10.1002/jcb.29574), has been retracted by agreement between the journal's Editor in Chief, Prof. Dr. Christian Behl, and Wiley Periodicals LLC. The retraction has been agreed after the authors asked to correct their article. The investigation additionally revealed several flaws and inconsistencies between results presented and experimental methods described. Thus, the editors consider the conclusions of this article to be invalid. The authors were not available for a final confirmation of the retraction.
Insights
This study on osteosarcoma metastasis has been retracted due to significant flaws. The article "LINC00657 activates PD-L1 to promote osteosarcoma metastasis via miR-106a" is no longer considered valid.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Context:
- The article investigated the role of LINC00657 in osteosarcoma metastasis.
- It proposed a mechanism involving PD-L1 and miR-106a.
Purpose:
- To present findings on the molecular mechanisms driving osteosarcoma metastasis.
- To highlight the interaction between LINC00657, PD-L1, and miR-106a.
Summary:
- The article "LINC00657 activates PD-L1 to promote osteosarcoma metastasis via miR-106a" has been retracted.
- Retraction was due to author-requested corrections revealing flaws and inconsistencies.
- Editors deemed the presented conclusions invalid due to experimental discrepancies.
Impact:
- The scientific conclusions of this study are invalidated.
- This retraction affects the body of research on osteosarcoma metastasis mechanisms.
- It underscores the importance of rigorous verification in scientific publishing.
Related Concept Videos
Clot Retraction and Fibrinolysis
Somatic Spinal Reflexes
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
Cell Motility through Blebbing
Blebbing Through the Matrix
In multicellular...
Relaxation of Skeletal Muscles
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
Types of Membrane Protrusions
The microvilli, an example of stable protrusions, are finger-like projections...
GPCR Desensitization

