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Updated: Sep 22, 2025
10:21
Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins
Published on: June 20, 2019
24.3K
[Fatty acid synthase, a "multi-FASet" enzyme].
1Université de Lille, CNRS, UMR 8576 - UGSF - Unité de glycobiologie structurale et fonctionnelle, F-59000, Lille, France.
Medecine Sciences : M/S
|May 24, 2022
Summary
Fatty acid synthase (FASN) is crucial for energy storage and cellular functions like division and proliferation. This review explores FASN
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Fatty acids are essential nutrients obtained from diet or synthesized endogenously.
- Fatty acid synthase (FASN) is a key enzyme in de novo fatty acid synthesis.
- FASN plays a vital role beyond energy storage, impacting cellular processes.
Purpose of the Study:
- To review the diverse physiological functions of fatty acid synthase (FASN).
- To examine the significant involvement of FASN in the development and progression of cancer.
- To highlight the elevated expression of FASN in cancerous tissues.
Main Methods:
- Literature review of existing research on FASN.
- Analysis of studies detailing FASN's role in normal physiology.
- Examination of evidence linking FASN expression to various cancer types.
Main Results:
- FASN is integral to synthesizing membrane components required for cell division.
- FASN activity is implicated in protein modification, cell signaling, and proliferation.
- Overexpression of FASN is a common characteristic of many cancers.
Conclusions:
- FASN is a multifunctional enzyme with critical roles in normal mammalian physiology.
- Dysregulation of FASN, particularly its high expression, is strongly associated with cancer.
- Targeting FASN may represent a potential therapeutic strategy for cancer treatment.
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