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Updated: Sep 22, 2025

Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins
Published on: June 20, 2019
[Fatty acid synthase, a "multi-FASet" enzyme]
1Université de Lille, CNRS, UMR 8576 - UGSF - Unité de glycobiologie structurale et fonctionnelle, F-59000, Lille, France.
Abstract:
In mammals, fatty acids are supplied by diet or synthesized de novo by fatty acid synthase (FASN). Beyond its key role in energy storage, FASN is involved in many biological processes. It actively participates in the synthesis of membrane components necessary for cell division, protein modification, cell signaling and cell proliferation. In this review, we discuss the various physiological functions of FASN as well as its involvement in cancer, the expression of the lipogenic enzyme being particularly high in this disease.
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