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Human Acellular Dermal Allograft Patch on Traumatic Tympanic Membrane Perforation.

Dong-Han Lee¹, Cha-Dong Yeo², Young Ho Kim²

¹Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Medical Center, Seoul, Republic of Korea.

The Journal of International Advanced Otology

|May 24, 2022

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Human acellular dermal allografts and paper patches show similar healing rates for traumatic tympanic membrane perforations. However, the dermal allograft patch remained in place longer, aiding successful healing.

Area of Science:

Otolaryngology
Regenerative Medicine
Biomaterials Science

Background:

Traumatic tympanic membrane perforation is a common otologic injury.
Current treatment options include conservative management and surgical repair.
The use of biomaterials as tympanic membrane patches is an evolving area of research.

Purpose of the Study:

To compare the efficacy of human acellular dermal allograft (HADA) patches versus conventional paper patches for traumatic tympanic membrane perforation.
To evaluate healing rates, recovery times, and patch maintenance durations between the two patch types.

Main Methods:

Retrospective study of 41 patients (42 ears) with traumatic tympanic membrane perforation.
Treatment groups: 22 HADA patches and 20 paper patches.

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Analysis of patient demographics, perforation characteristics, healing outcomes, and audiological data.

Main Results:

No significant differences in recovery confirmation time or recovery rate between HADA and paper patch groups.
HADA group demonstrated a statistically longer patch maintenance time (32.9 days vs. 15.6 days).
Patch material was significantly associated with patch maintenance time.

Conclusions:

Human acellular dermal allografts offer comparable therapeutic efficacy to paper patches for traumatic tympanic membrane perforations.
A key advantage of HADA is its prolonged in-situ duration, facilitating successful healing.
HADA represents a viable alternative for tympanic membrane closure.