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Updated: Sep 22, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
[3 + 1] Mixed Cyclization: A Synthetic Route to Prepare Low-Symmetry Phthalocyanines
Joseph Y M Chan1, Dennis K P Ng1
1Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Abstract:
A novel synthetic strategy for low-symmetry phthalocyanines has been developed, which involves the base-promoted cyclization of a preconnected trisphthalonitrile and a free phthalonitrile in the presence of a metal template. By using this [3 + 1] mixed cyclization approach, a series of zinc(II) phthalocyanine derivatives have been synthesized in up to 12% yields, including a very rare ABCD-type phthalocyanine and an amphiphilic ABAC-type analogue that can self-assemble in aqueous media, forming stable spherical nanoparticles.
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