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Related Experiment Video

Updated: Sep 22, 2025

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

Human organoids in basic research and clinical applications.

Xiao-Yan Tang¹, Shanshan Wu¹, Da Wang¹

¹Institute for Stem Cell and Neural Regeneration, School of Pharmacy; State Key Laboratory of Reproductive Medicine; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine; Nanjing Medical University, Nanjing, China.

Signal Transduction and Targeted Therapy

|May 24, 2022

Summary

This summary is machine-generated.

Organoids are 3D in vitro models of human organs derived from stem cells. These patient-derived organoids offer promising applications in drug testing, regenerative medicine, and understanding human development.

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Area of Science:

Biotechnology
Developmental Biology
Stem Cell Research

Background:

Organoids are 3D in vitro models that mimic human organ structure and function.
They are derived from human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs).
Organoids recapitulate organ heterogeneity and developmental processes.

Purpose of the Study:

To provide an update on current organoid differentiation technologies.
To discuss applications of stem cell-derived organoids in research and clinics.
To outline challenges in organoid utilization.

Main Methods:

Review of in vitro differentiation technologies for various organoids (brain, retinal, kidney, liver, lung, gastrointestinal, cardiac, vascularized, multi-lineage).
Comparison of PSC- and AdSC-derived organoids.
Summary of organoid applications and limitations.

Main Results:

Successful generation of diverse organoid types mimicking in vivo organs.
Organoids derived from patients hold promise for personalized medicine and drug testing.
Advancements in organoid technology enhance study of human physiology and development.

Conclusions:

Stem cell-derived organoids are valuable tools for basic research and clinical applications.
Further understanding of organoid mechanisms will deepen insights into human development.
Organoids are crucial for advancing regenerative medicine, gene repair, and transplantation therapies.