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Immunoselective Cellulose Nanospheres: A Versatile Platform for Nanotheranostics
Christopher Carrick1, Lars Wågberg2, Per A Larsson2
1School of Chemical Science and Engineering, Department of Fibre and Polymer Technology and ‡Wallenberg Wood Science Center, WWSC, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden.
ACS Macro Letters
|May 25, 2022
Summary
Researchers developed novel cellulose nanospheres (CNSs) for theranostics. These spheres allow for surface and bulk functionalization, enabling targeted cancer cell interaction and diagnostic imaging.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Theranostics
Background:
- Cellulose nanospheres (CNSs) offer potential for biomedical applications due to their biocompatibility and tunable properties.
- Current methods for CNS functionalization may limit their utility in complex applications like theranostics.
- Targeted delivery and imaging are crucial for effective cancer theranostics.
Purpose of the Study:
- To develop a novel method for preparing and functionalizing perfectly spherical cellulose nanospheres (CNSs).
- To demonstrate the utility of functionalized CNSs for targeted cancer cell interaction and diagnostic imaging in theranostics.
- To explore the potential of CNSs for both surface and bulk modifications.
Main Methods:
- Preparation of perfectly spherical cellulose nanospheres (CNSs) with controlled diameters (100-400 nm).
- Surface functionalization of CNSs via antibody conjugation, specifically targeting the epidermal growth factor receptor (EGFR).
- Bulk functionalization of CNSs by embedding gold nanoparticles for enhanced imaging contrast.
Main Results:
- Achieved uniform spherical CNSs with diameters typically between 160-170 nm.
- Demonstrated specific binding of antibody-conjugated CNSs to EGFR-expressing cancer cells with minimal nonspecific binding.
- Successfully embedded gold nanoparticles within the CNS matrix for diagnostic imaging capabilities.
Conclusions:
- The novel preparation and functionalization route enables versatile CNS applications in theranostics.
- Functionalized CNSs show high specificity for targeted cancer cell interactions.
- The ability for bulk functionalization with nanoparticles opens avenues for diagnostic imaging integration.
