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Light-Triggered Switching of Reversible and Alterable Biofunctionality via β-Cyclodextrin/Azobenzene-Based Host-Guest
Jie Deng1, Xinyue Liu1, Wenbin Shi1
1College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
ACS Macro Letters
|May 25, 2022
Summary
This study introduces a novel light-triggered method for switching biofunctions on silicon surfaces. The smart monolayers offer reversible antibacterial/hemostatic to bioadhesion/anticoagulant properties using UV-vis light cycles.
Area of Science:
- Biomaterials Science
- Surface Chemistry
- Photochemistry
Background:
- Recent research focused on reversible biomolecule immobilization using cyclodextrin/azobenzene/polymer systems.
- Reversible photoswitching of biofunctions using cost-effective strategies remains underexplored.
Purpose of the Study:
- To develop a light-triggered system for reversible and alterable biofunctionality on silicon interfaces.
- To utilize β-cyclodextrin/azobenzene host-guest interactions for creating smart surfaces.
Main Methods:
- Synthesis of biofunctional azobenzene-grafted polymers.
- Assembly of polymers onto β-cyclodextrin anchored silicon interfaces.
- Characterization of photoresponsive interfaces and their biofunctionality switching.
Main Results:
- Demonstrated light-triggered switching of reversible and alterable biofunctionality.
- Achieved switching from antibacterial/hemostatic to bioadhesion/anticoagulant states.
- Confirmed the effectiveness of UV-vis light cycles for reversible switching.
Conclusions:
- Developed a novel strategy for creating "smart" monolayers with switchable biofunctions.
- The β-cyclodextrin/azobenzene system enables precise control over surface bioactivity.
- Potential applications in advanced biomedical devices and materials.
