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Introducing critical common dysregulated proteins in esophageal, gastric, and intestinal cancers
Babak Arjmand1, Mohammadreza Razzaghi2, Mostafa Rezaei Tavirani3
1Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Aim:
The current study aimed to determine the common dysregulated proteins between esophageal, gastric, and intestinal cancers.
Background:
Though there are several documents about the role of AKT1 in promoting of esophageal, gastric, and intestinal cancers, there is not enough evidence about the dominant role of AKT1 relative to the other oncogene genes in the promotion of the three studied cancer types.
Methods:
One hundred proteins related to each of esophageal, gastric, or intestinal cancer were retrieved from the STRING database and interacted by Cytoscape software v 3.2.7. 2 to create the correlated interactomes. The network was analyzed by the "NetworkAnalyzer" application of Cytoscape to find the centrality parameters of the nodes. Results of network analysis and action map assessment were used to determine the common critical proteins between the three studied cancers.
Results:
One hundred proteins were extracted for each of the studied cancers. Among 42 common dysregulated proteins, 36 individuals were selected through network analysis and were screened through action map assessment. Eighteen proteins were introduced as the important common proteins. Finally, AKT1 was a candidate for the crucial dysregulated proteins common in the three analyzed diseases.
Conclusion:
The findings indicate that AKT1, relative to the other oncogene genes, is a suitable candidate to be evaluated in patients as a prediagnostic tool to reduce endoscopy and colonoscopy rates.
Insights
The study identified AKT1 as a key common dysregulated protein across esophageal, gastric, and intestinal cancers. This finding suggests AKT1
Area of Science:
- Oncology
- Molecular Biology
- Bioinformatics
Background:
- Esophageal, gastric, and intestinal cancers share common oncogenic pathways.
- The specific role of AKT1 in promoting these three cancer types requires further elucidation relative to other oncogenes.
Purpose of the Study:
- To identify common dysregulated proteins among esophageal, gastric, and intestinal cancers.
- To determine the potential of these proteins as diagnostic biomarkers.
Main Methods:
- Utilized the STRING database to retrieve cancer-related proteins.
- Employed Cytoscape software for network construction and analysis.
- Applied NetworkAnalyzer to identify critical protein nodes and common dysregulated proteins.
Main Results:
- Identified 18 common critical proteins across the three cancer types.
- Highlighted AKT1 as a crucial dysregulated protein common to esophageal, gastric, and intestinal cancers.
- Network analysis revealed AKT1's significant role in the interactomes of these cancers.
Conclusions:
- AKT1 is a promising candidate for a prediagnostic tool in esophageal, gastric, and intestinal cancers.
- Evaluating AKT1 could potentially reduce the need for invasive procedures like endoscopy and colonoscopy.
- Further validation of AKT1 as a biomarker is warranted for clinical application.
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