Recent advances in biomaterial-assisted cell therapy.

Area of Science:

• Biomedical Engineering
• Cell Biology
• Regenerative Medicine

Background:

• Chimeric antigen receptor (CAR)-T cell therapy highlights the potential of cell-based medicines.
• Cells offer low immunogenicity and biological barrier crossing capabilities.
• Significant challenges remain for clinical translation, including manufacturing and toxicity.

Purpose of the Study:

• To review recent advances in cell-based therapeutics.
• To outline the role of biomaterials in developing cell-based therapies.
• To provide a perspective on cell therapies, focusing on biomaterial integration.

Main Methods:

• Literature review of cell-based therapeutics.
• Analysis of biomaterial applications in cell therapy development.
• Discussion of future perspectives in cell-based biopharmaceuticals.

Main Results:

• Biotechnology and materials science offer solutions to cell therapy challenges.
• Biomaterials can enhance the preparation, stability, and delivery of cell therapies.
• Various cells are being explored as bioactive components in therapeutics.

Conclusions:

• Biomaterial-assisted cell therapies are crucial for overcoming clinical translation hurdles.
• Integrating biomaterials is key to advancing cell-based biopharmaceuticals.
• This approach promises wider applications in disease treatment.