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Role of HLA genes in development of HLA-alloimmunization in blood recipients

E V Butina1, F S Sherstnev1, O D Maksimov1

  • 1Federal State Budget Institution of Science «Kirov Scientific Research Institute of Hematology and Blood Transfusion of the Federal Medical-Biological Agency».

Klinicheskaia Laboratornaia Diagnostika
|May 25, 2022
PubMed

A genetically determined predisposition to the development of HLA-alloimmunization as a result of blood transfusions is associated with the presence of HLA-alleles DRB1*04, DQA1*03:01, DQA1*05:01 and HLA-haplotype DRB1*04-DQA1*03:01-DQB1*03:02 in the genotypes of recipients. The risk of antibody production is reduced in patients with HLA-alleles DRB1*16, DQA1*01:02, DQB1*05:02 and HLA-haplotype DRB1*16-DQA1*01:02-DQB1*05:02.

Keywords:
HLAalloantibodiesalloimmunizationantigensgensplatelet transfusion

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