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Updated: Sep 22, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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Retraction Note: γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised

Laura Steenbergen1, Roberta Sellaro2, Ann-Kathrin Stock3

  • 1Institute for Psychological Research, Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands. l.steenbergen@fsw.leidenuniv.nl.

Scientific Reports
|May 25, 2022
PubMed
Summary

No abstract available in PubMed .

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γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
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