Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reduction/photo dual-responsive polymeric prodrug nanoparticles for programmed siRNA and doxorubicin delivery.

Biomaterials science·2018
Same author

Photoresponsive Nanovehicle for Two Independent Wavelength Light-Triggered Sequential Release of P-gp shRNA and Doxorubicin To Optimize and Enhance Synergistic Therapy of Multidrug-Resistant Cancer.

ACS applied materials & interfaces·2018
Same author

Patient-Controlled Paravertebral Block for Video-Assisted Thoracic Surgery: A Randomized Trial.

The Annals of thoracic surgery·2018
Same author

Chemotherapeutic Drug Based Metal-Organic Particles for Microvesicle-Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2018
Same author

The function of Notch1 intracellular domain in the differentiation of gastric cancer.

Oncology letters·2018
Same author

Enabling Photon Upconversion and Precise Control of Donor-Acceptor Interaction through Interfacial Energy Transfer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2018

Related Experiment Video

Updated: Sep 22, 2025

Phase Behavior of Charged Vesicles Under Symmetric and Asymmetric Solution Conditions Monitored with Fluorescence Microscopy
10:08

Phase Behavior of Charged Vesicles Under Symmetric and Asymmetric Solution Conditions Monitored with Fluorescence Microscopy

Published on: October 24, 2017

9.3K

Release Behavior of Polymeric Vesicles in Solution Controlled by External Electrostatic Field.

Ming Wu1,2, Yutian Zhu1, Wei Jiang1

  • 1State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.

ACS Macro Letters
|May 26, 2022
PubMed
Summary

Electrostatic fields can break down polymer vesicles into smaller sizes, enabling controlled release of encapsulated molecules like Nile Red. This offers a novel method for precise drug delivery applications.

More Related Videos

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure
06:01

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure

Published on: April 21, 2021

3.3K
Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration
09:29

Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration

Published on: January 19, 2020

8.6K

Related Experiment Videos

Last Updated: Sep 22, 2025

Phase Behavior of Charged Vesicles Under Symmetric and Asymmetric Solution Conditions Monitored with Fluorescence Microscopy
10:08

Phase Behavior of Charged Vesicles Under Symmetric and Asymmetric Solution Conditions Monitored with Fluorescence Microscopy

Published on: October 24, 2017

9.3K
Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure
06:01

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure

Published on: April 21, 2021

3.3K
Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration
09:29

Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration

Published on: January 19, 2020

8.6K

Area of Science:

  • Polymer science and materials chemistry
  • Supramolecular chemistry and self-assembly
  • Nanotechnology and drug delivery

Background:

  • Amphiphilic block copolymers self-assemble into polymeric vesicles (polymersomes).
  • Polymersomes are promising nanocarriers for drug delivery and other applications.
  • External stimuli responsiveness is key for controlled release applications.

Purpose of the Study:

  • To investigate the effect of electrostatic fields on polymeric vesicles.
  • To explore the potential of electrostatic fields for controlled release of encapsulated substances.
  • To provide a novel method for manipulating polymersomes in solution.

Main Methods:

  • Self-assembly of polystyrene-block-poly(acrylic acid) (PS-b-PAA) block copolymers.
  • Deformation and fission of polymersomes induced by external electrostatic fields.
  • Encapsulation and controlled release of Nile Red (NR) dye molecules.

Main Results:

  • Polymeric vesicles deform, break, and divide into smaller vesicles under electrostatic fields.
  • Vesicle size is inversely proportional to electrostatic field intensity.
  • Accurate control over Nile Red release by adjusting field intensity and time.

Conclusions:

  • Electrostatic fields provide a powerful tool for controlling polymersome morphology and stability.
  • This work demonstrates a new, convenient approach for triggered release from polymersomes.
  • Findings contribute to understanding external field-induced transformations of polymer nanostructures.