Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Poly(sulfobetaine-<i>co</i>-oligoethylene Glycol Methyl Ether Methacrylate) Copolymers with Improved Anti-Fouling and Anti-Coagulant Properties.

Biomacromolecules·2026

Same author

Long-Term Hydrophilic, Anti-Clotting, and Anti-Fibrotic Dynamic Covalent Silicone-Based Biomaterials.

Advanced healthcare materials·2026

Same author

Nanovesicle-Based Delivery of Magnesium Chlorophyllin for Photodynamic Inactivation in Agriculture.

Small science·2026

Same author

A Real-Time Antifouling Multivalent Aptamer Platform for Wash-Free Electrochemical Detection of Low-Abundance Biomarkers in Human Plasma.

Angewandte Chemie (International ed. in English)·2026

Same author

Ultrasound-triggered drug delivery: recent developments and opportunities.

Therapeutic delivery·2025

Same author

Antibiotic-Loaded Calcium Crosslinked Alginate Wound Dressings Fabricated via Pressurized Gas eXpanded Liquids Technology in Combination with Supercritical Adsorptive Precipitation for Treating Methicillin-Resistant <i>Staphylococcus</i> Infections.

ACS applied bio materials·2025

Search research articles

Related Experiment Video

Updated: Sep 22, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Injectable Interpenetrating Network Hydrogels via Kinetically Orthogonal Reactive Mixing of Functionalized Polymeric

Trevor Gilbert¹, Niels M B Smeets¹, Todd Hoare¹

¹Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L7, Canada.

ACS Macro Letters

|May 26, 2022

Summary

Researchers developed injectable, thermoresponsive interpenetrating polymer networks (IPNs) using poly(N-isopropylacrylamide) and poly(N-vinylpyrrolidone). These novel IPNs form rapidly after injection, offering enhanced mechanics for biomedical applications.

More Related Videos

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

Related Experiment Videos

Last Updated: Sep 22, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

Area of Science:

Biomaterials Science
Polymer Chemistry
Biomedical Engineering

Background:

Interpenetrating polymer networks (IPNs) show promise for biomedical applications due to enhanced mechanics and unique properties.
Conventional IPNs are often not injectable, limiting their in vivo utility.
Developing injectable hydrogels is crucial for minimally invasive biomedical interventions.

Purpose of the Study:

To create a fully injectable and thermoresponsive interpenetrating polymer network (IPN) hydrogel.
To overcome the limitations of conventional IPNs in biomedical applications.
To investigate the synergistic mechanical and physical properties of the novel IPN system.

Main Methods:

Simultaneous reactive mixing of hydrazone cross-linked poly(N-isopropylacrylamide) (PNIPAM) and thiosuccinimide cross-linked poly(N-vinylpyrrolidone) (PVP).
Assessment of gelation time and injectability post-mixing.
Characterization of mechanical properties (shear storage modulus), pore morphology, degradation kinetics, and thermal swelling behavior.

Main Results:

The developed IPN hydrogels exhibit rapid gelation (<1 min) after injection without external triggers.
IPNs demonstrate significantly enhanced shear storage modulus compared to individual component networks.
Distinctive pore morphology, tunable degradation kinetics, and reduced thermal phase transition hysteresis were observed.

Conclusions:

The novel injectable and thermoresponsive IPN hydrogels offer a promising platform for advanced biomedical applications.
The kinetically orthogonal cross-linking strategy leads to synergistic improvements in material properties.
These findings pave the way for new injectable biomaterials with tailored functionalities.