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Updated: Sep 22, 2025

Microfluidic Model to Mimic Initial Event of Neovascularization
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Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model.

Huanli Sun1, Mattias Björnmalm2, Jiwei Cui2

  • 1ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and ‡Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.

ACS Macro Letters
|May 26, 2022
PubMed
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Soft hyaluronic acid (HA) particles and capsules mimic red blood cells (RBCs). Particle structure, not just stiffness, dictates how these bionano materials flow through microcapillaries.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Biophysics

Background:

  • Particle stiffness is a critical factor influencing interactions with biological systems, affecting biodistribution and cellular processing.
  • Designing synthetic particles that mimic the mechanical properties and behavior of biological cells, like red blood cells (RBCs), is crucial for advanced biomedical applications.

Purpose of the Study:

  • To develop soft polysaccharide (hyaluronic acid, HA) replica particles and capsules with tunable stiffness and size comparable to human RBCs.
  • To investigate the relationship between nanoscale stiffness and macroscopic deformability of these HA-based materials in a physiologically relevant microfluidic model.

Main Methods:

  • Fabrication of HA replica particles and capsules using atom transfer radical polymerization-mediated continuous assembly of polymers (CAPATRP).

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  • Measurement of nanoscale stiffness using colloidal-probe atomic force microscopy (CP-AFM).
  • Assessment of deformability and flow behavior using a microfluidic blood capillary model.

    • Main Results:

    • HA replica particles and capsules with similar nanoscale stiffness exhibited distinct behaviors in the microfluidic blood capillary model.
    • HA capsules demonstrated RBC-like passage through capillaries, while HA particles experienced difficulty.
    • Flow-based deformability measurements provided complementary insights to nanoscale stiffness data.

    Conclusions:

    • Particle structure, in addition to nanoscale stiffness, significantly impacts the flow-based deformability of soft replica materials.
    • The study highlights the utility of combining AFM stiffness measurements with microfluidic flow models for characterizing biomimetic particles.
    • Findings offer valuable insights for the design of soft nanoparticles and capsules for biomedical applications requiring specific flow dynamics.