Related Experiment Video
Updated: Sep 22, 2025
09:41
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
8.7K
Real World Multiple Myeloma Registry from Jordan, a Developing Country
Farah Qasem1, A'sem Abu-Qamar1, Batool Aqel1
1Medical school, The University of Jordan, Amman, Jordan.
Summary
This study reviews a Multiple Myeloma (MM) registry in Jordan, finding median survival of 38 months. Improved treatment strategies are needed for MM patients in developing regions.
Area of Science:
- Hematology
- Oncology
- Epidemiology
Background:
- Limited data exists on Multiple Myeloma (MM) in the Middle East and North Africa (MENA) region.
- A Multiple Myeloma registry was established at Jordan University Hospital (JUH) in 2009.
- This study analyzes data from 113 MM patients diagnosed at JUH.
Purpose of the Study:
- To review the Multiple Myeloma registry at Jordan University Hospital.
- To analyze the management and clinical course of MM patients in Jordan.
- To provide insights into MM epidemiology and treatment in a developing country context.
Main Methods:
- Retrospective analysis of a non-interventional Multiple Myeloma registry (2009-2016).
- Involved 113 patients diagnosed with MM at Jordan University Hospital.
- Statistical analysis using SPSS; Overall Survival (OS) analyzed with Kaplan-Meier method.
Main Results:
- Median age of MM patients was 62 years; no gender difference observed.
- Most patients presented with advanced disease (ISS stages II and III) and bone pain.
- Median overall survival was 38 months, significantly lower for advanced ISS stages.
Conclusions:
- Multiple Myeloma management in developing countries like Jordan presents unique challenges.
- The study highlights the need for improved MM care roadmaps and access to advanced therapies.
- Future improvements in survival and quality of life are anticipated with wider use of combination therapies.
More Related Videos
05:32Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
Published on: January 7, 2019
6.9K
10:04Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
13.2K
Related Concept Videos
01:22Bone Marrow Sampling and Transplants
516
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
516
02:43Mouse Models of Cancer Study
5.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.7K
01:21Cancer Survival Analysis
463
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
463
02:56Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
01:16Clinical Trials
9.3K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
9.3K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.5K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.5K