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Updated: Sep 22, 2025

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Erectile Dysfunction in Patients with Multiple Chronic Conditions: A Cross- Sectional Study.

Giuseppe Lisco¹, Nicola Bartolomeo², Maria Isabella Ramunni³

¹Section of Internal Medicine, Geriatrics, Endocrinology, and Rare Disease, Interdisciplinary Department of Medicine, University of Bari, School of Medicine, Policlinico, Bari, Italy.

Endocrine, Metabolic & Immune Disorders Drug Targets

|May 26, 2022

Summary

Erectile dysfunction (ED) prevalence significantly increases with chronic disease severity. A modified Charlson Comorbidity Index (mCCI) shows promise for assessing comorbidity burden in men with ED.

Keywords:

Charlson comorbidity index Erectile dysfunction comorbidities cross-sectional study type 2 diabetes

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Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Published on: June 16, 2014

Area of Science:

Urology
Andrology
Internal Medicine

Background:

Erectile dysfunction (ED) prevalence escalates with the number and severity of chronic diseases.
Chronic conditions significantly impact male sexual health and overall well-being.

Purpose of the Study:

To assess the frequency and severity of ED in patients with multiple chronic conditions.
To evaluate the correlation between ED, comorbidity indices, and total testosterone levels.
To compare the performance of the Charlson Comorbidity Index (CCI) and a modified CCI (mCCI).

Main Methods:

Utilized the 5-item International Index of Erectile Function questionnaire (IIEF-5) for ED diagnosis and classification.
Employed the Charlson Comorbidity Index (CCI) to quantify the burden of chronic comorbidities.
Assessed correlations between IIEF-5, total testosterone (TT), CCI, and mCCI.

Main Results:

ED frequency rose with CCI severity: 45% (CCI=0) to 99% (CCI≥3) (p<.0001).
CCI negatively correlated with TT levels and IIEF-5 scores (r=-0.34 and -0.44; p<.0001).
The proposed mCCI demonstrated comparable performance to the CCI.

Conclusions:

ED frequency and severity are significant concerns in outpatients with sexual complaints and comorbidities.
The mCCI may serve as a reliable tool for assessing the cumulative burden of chronic conditions.
ED can be considered a potential indicator of overall male health, warranting further investigation.