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Therapeutic Effectiveness of a Dietary Supplement for Management of Halitosis in Dogs

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Effectiveness of pediatric nasal irrigation solution with or without xylitol.

Yücel Kurt¹, Yavuz Selim Yildirim²

¹KBB Uzmanı, Antalya Finike Devlet hastanesi, Turkey.

International Journal of Pediatric Otorhinolaryngology

|May 26, 2022

Summary

Daily hypertonic saline nasal irrigation is effective for pediatric chronic rhinosinusitis (CRS). Xylitol irrigation showed poor tolerance and is not recommended for children with CRS.

Keywords:

Chronic rhinosinusitis Nasal irrigation Pediatric Quality of life Saline irrigation Xylitol

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Area of Science:

Otolaryngology
Pediatric Medicine
Medical Research

Background:

Pediatric chronic rhinosinusitis (CRS) significantly impacts children's quality of life.
Current treatment options for pediatric CRS require evaluation for efficacy and patient tolerance.

Purpose of the Study:

To compare the efficacy and outcomes of daily hypertonic saline irrigation versus saline/xylitol irrigation in treating pediatric CRS.
To assess the impact of these treatments on patients' quality of life.

Main Methods:

A prospective, randomized, single-blinded study involving 125 children diagnosed with CRS.
Participants received twice-daily intranasal irrigations with either hypertonic saline or saline/xylitol for six weeks.
Treatment outcomes were measured using the Sinonasal Quality of Life Survey (SN-5) at baseline and after six weeks.

Main Results:

Hypertonic saline irrigation led to statistically significant improvements in four domains of the SN-5 score and overall quality of life compared to baseline.
No significant differences were observed in SN-5 scores between the hypertonic saline and xylitol groups post-treatment.
The xylitol solution group showed no improvement in any SN-5 domain or overall score.

Conclusions:

Xylitol irrigation is not recommended as a first-line treatment for pediatric CRS due to low tolerance, compliance, and side effects.
Twice-daily, large-volume, low-pressure hypertonic saline nasal irrigation for six weeks is a safe and effective baseline treatment for pediatric CRS.
Hypertonic saline irrigation can be considered a foundational therapy before surgical interventions for pediatric CRS.