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Updated: Sep 22, 2025

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
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The CD8α hinge is intrinsically disordered with a dynamic exchange that includes proline cis-trans isomerization

Xiang Chen1, Justin M Mirazee2, Katarzyna A Skorupka3

  • 1Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|May 26, 2022
PubMed
Summary

Chimeric antigen receptor (CAR) T-cell therapy shows promise. A CD8α hinge region in CARs enhances leukemia cell killing by promoting structural plasticity, improving antigen binding and signaling.

Keywords:
CAR T-cellCD8Intrinsically disordered proteinsLinkerProline isomerization

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