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Updated: Sep 22, 2025

A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing

A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing

Published on: February 4, 2017

Metabolic interactions shape a community's phenotype.

Chrats Melkonian¹, Michael F Seidl², Justin J J van der Hooft³

¹Theoretical Biology & Bioinformatics Group, Department of Biology, Utrecht University, 3584CH Utrecht, The Netherlands; Bioinformatics Group, Wageningen University, Droevendaalsesteeg 1, 6708, PB, Wageningen, The Netherlands.

Trends in Microbiology

|May 26, 2022

Summary

This summary is machine-generated.

Microbial communities with nutrient-dependent auxotrophs and self-sufficient prototrophs show altered fitness. Metabolism, both inside cells and between them, impacts community health under normal conditions and drug stress.

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High-Throughput Metabolic Profiling for Model Refinements of Microalgae

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Published on: December 4, 2021

Area of Science:

Microbial Ecology
Systems Biology
Metabolic Interactions

Background:

Metabolic interactions between auxotrophs and prototrophs are crucial for microbial community structure and function.
Understanding these interactions is essential for predicting community behavior under various environmental conditions.

Purpose of the Study:

To investigate the impact of intracellular and intercellular metabolic exchanges on microbial community fitness.
To determine how abiotic stress, such as drugs, influences these metabolic interactions and overall community health.

Main Methods:

Utilized a microbial community model composed of auxotrophic and prototrophic strains.
Analyzed metabolic profiles and community dynamics under different conditions (absence and presence of drugs).

Main Results:

Demonstrated that metabolic interactions significantly influence community fitness.
Showed that both intracellular and intercellular metabolism play critical roles.
Identified differential effects of drug stress on metabolic interactions and community stability.

Conclusions:

Metabolic interactions are a key determinant of microbial community fitness.
Community resilience to abiotic stress is modulated by metabolic strategies.
Further research into metabolic cross-feeding is warranted.