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Updated: Sep 21, 2025

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Role of Direct Oral Anticoagulants for Post-operative Venous Thromboembolism Prophylaxis

Han Naung Tun1, May Thu Kyaw2, Erik Rafflenbeul3

  • 1Larner College of Medicine, University of Vermont Burlington, VT, US.

European Cardiology
|May 27, 2022
PubMed

Venous thromboembolism (VTE) is one of the leading causes of post-operative morbidity and mortality. Over previous decades, heparin and warfarin were the predominant therapeutic options for post-operative thromboprophylaxis. However, their use is limited by drawbacks including a narrow therapeutic range, numerous food and drug interactions, and the need for regular monitoring for dose adjustments. Recently, direct oral anticoagulants (DOACs), such as dabigatran etexilate (a direct thrombin inhibitor) and apixaban, rivaroxaban and edoxaban (direct factor Xa inhibitors), have been developed to overcome these issues. DOACs have shown promising results in Phase III clinical trials for post-operative VTE prophylaxis. This review summarises the pharmacological profile of DOACs and highlights the use of DOACs in post-operative VTE prophylaxis based on the available clinical trial data.

Keywords:
Direct oral anticoagulantsdeep vein thrombosispost-operativevenous thromboembolism

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