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Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
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Investigation of predictors of bleeding complications in COVID-19 using rotational thromboelastometry (ROTEMⓇ): A

Ayaka Matsuoka1, Hiroyuki Koami1, Kota Shinada1

  • 1Department of Emergency and Critical Care Medicine, Faculty of Medicine Saga University Saga City Saga Japan.

Health Science Reports
|May 27, 2022
PubMed

Insights

Rotational thromboelastometry (ROTEM) can predict bleeding complications in severe COVID-19 patients. Specific ROTEM parameters and prothrombin time international normalized ratio (PT-INR) at admission are key indicators for identifying patients at risk of bleeding.

Area of Science:

  • Critical Care Medicine
  • Hematology
  • Infectious Diseases

Background:

  • Hemorrhagic complications in COVID-19 are rare but linked to poor prognosis.
  • Identifying bleeding risk factors in COVID-19 patients is crucial for management.

Purpose of the Study:

  • To identify risk factors for bleeding complications in COVID-19 patients.
  • To evaluate the utility of rotational thromboelastometry (ROTEM) and blood tests in predicting bleeding events.

Main Methods:

  • Retrospective study of 31 severe COVID-19 patients.
  • Comparison of ROTEM parameters and blood tests between bleeding and non-bleeding groups.
  • Analysis using receiver operating curve and logistic regression.

Main Results:

  • Significant differences in ROTEM values were observed between groups.
  • Prothrombin time international normalized ratio (PT-INR) and EXTEM A10 showed high predictive value (AUC 0.82 and 0.81).
  • Logistic regression indicated PT-INR and EXTEM A10 as significant predictors of bleeding.

Conclusions:

  • ROTEM parameters, particularly EXTEM A10, are sensitive predictors of bleeding complications in COVID-19.
  • Early identification of bleeding risk using ROTEM can aid clinical decision-making.
Abstract

Keywords:
anticoagulationcoagulopathypoint of care testingprothrombin time

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