Beyond the hippocampus: boundary conditions for cortical connectivity and activity over time

By including four different time intervals and controlling for behavioral confounds, Tallman et al. (this issue) found that brain connectivity of cortical regions with the vmPFC or with the hippocampus changed over time, although hippocampal activity did not change significantly. This study shed light on how memory is consolidated as it ages. Further studies could clarify the extent to which other factors, such as memory content, influence brain connectivity with more than two time intervals. The roles of different cortical regions in memory consolidation should also be addressed.