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Triglyceride Glucose Index for Predicting Major Adverse Cardiovascular Events in Chinese Patients with Hypertension

Fomin Zhang1, Rena Kadierding1, Shihan Zhang1

  • 1Thoracic Clinical College, 12610Tianjin Medical University, Tianjin, China.

Angiology
|May 27, 2022
PubMed

Insights

The triglyceride glucose (TyG) index can predict major adverse cardiovascular events (MACE) in high-risk hypertensive patients. A higher TyG index indicates an increased risk of MACE development.

Area of Science:

  • Cardiology
  • Metabolic Syndrome Research
  • Hypertension Management

Background:

  • Cardiovascular disease remains a leading cause of mortality globally.
  • Hypertension is a major risk factor for cardiovascular events.
  • Identifying reliable prognostic markers for cardiovascular risk in hypertensive populations is crucial.

Purpose of the Study:

  • To investigate the prognostic value of the triglyceride glucose (TyG) index for major adverse cardiovascular events (MACE).
  • To assess the predictive capability of the TyG index in high-risk Chinese hypertensive patients.

Main Methods:

  • A longitudinal cohort study involving 2250 high-risk hypertensive patients from Tianjin, China.
  • Patients were categorized into low-TyG (≤8.87) and high-TyG (>8.87) index groups.
  • Univariate and multivariate Cox regression analyses were employed to evaluate the association between TyG index and MACE.

Main Results:

  • The high-TyG group exhibited a significantly higher risk of MACE (HR: 1.313, 95% CI: 1.010–1.708) compared to the low-TyG group.
  • The predictive value of the TyG index for MACE was more pronounced in subgroups of patients aged ≤65 years and males.
  • The TyG index demonstrated an independent association with the occurrence of MACE after adjusting for other risk factors.

Conclusions:

  • The triglyceride glucose (TyG) index serves as a valuable and independent indicator for predicting major adverse cardiovascular events (MACE) in hypertensive patients.
  • The TyG index may aid in risk stratification and management strategies for hypertensive individuals at high cardiovascular risk.

Keywords:
cohort studyhypertensioninsulin resistancemajor adverse cardiovascular eventstriglyceride glucose index

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