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Related Experiment Video

Updated: Sep 21, 2025

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

Published on: June 2, 2020

Engineering Extracellular Microenvironment for Tissue Regeneration.

Dake Hao^1,2, Juan-Maria Lopez¹, Jianing Chen¹

¹Department of Surgery, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.

Bioengineering (Basel, Switzerland)

|May 27, 2022

Summary

Engineering the extracellular microenvironment, including the extracellular matrix (ECM), extracellular vesicles (EVs), and growth factors (GFs), is key for controlling cell behavior and advancing tissue regeneration. This review explores methods to create artificial components for enhanced regenerative medicine applications.

Keywords:

cell behaviors extracellular matrix extracellular vesicles growth factors tissue regeneration

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Last Updated: Sep 21, 2025

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

Published on: June 2, 2020

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

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Published on: August 10, 2015

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

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Published on: June 16, 2015

Area of Science:

Biomaterials Science
Regenerative Medicine
Cellular Engineering

Background:

The extracellular microenvironment is a dynamic system of biochemical and biophysical cues essential for cell function and tissue regeneration.
Controlling the extracellular microenvironment is critical for directing cell behavior and achieving successful tissue repair.
Key components include the extracellular matrix (ECM), extracellular vesicles (EVs), and growth factors (GFs).

Purpose of the Study:

To review engineering approaches for extracellular microenvironment components (ECM, EVs, GFs).
To explore technologies for creating native-mimicking artificial components for tissue regeneration.
To provide a comprehensive analysis of current research in extracellular microenvironment engineering and monitoring.

Main Methods:

Review of existing literature on extracellular microenvironment components and engineering strategies.
Analysis of technologies used to engineer artificial ECM, EVs, and GFs.
Examination of methods for monitoring engineered extracellular microenvironments.

Main Results:

Engineering strategies offer enhanced control over cellular activities and behaviors.
Artificial, native-mimicking components show promise for improved regenerative applications.
Current research facilitates the development of innovative tissue engineering strategies.

Conclusions:

Extracellular microenvironment engineering is vital for advancing regenerative medicine.
Development of advanced biomaterials and technologies is crucial for future applications.
This review highlights the potential for innovative tissue engineering solutions.