Related Experiment Video

Updated: Sep 21, 2025

Standardizing a Non-Lethal Method for Characterizing the Reproductive Status and Larval Development of Freshwater Mussels Bivalvia: Unionida
07:22

Standardizing a Non-Lethal Method for Characterizing the Reproductive Status and Larval Development of Freshwater Mussels Bivalvia: Unionida

Published on: October 4, 2019

7.9K

Marine Migrastatics: A Comprehensive 2022 Update

Marzia Vasarri1, Emanuela Barletta1, Donatella Degl'Innocenti1,2

  • 1Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

Marine Drugs
|May 27, 2022
PubMed

Insights

Marine compounds show promise in preventing cancer metastasis by inhibiting cancer cell invasion. This review highlights natural products from the sea as potential migrastatics for improved cancer therapies.

Area of Science:

  • Marine biology
  • Cancer research
  • Pharmacology

Background:

  • Cancer metastasis significantly worsens patient prognosis.
  • Developing antimetastatic therapies is crucial for improving long-term survival.
  • Migrastatics offer a potential strategy to block cancer cell invasion.

Purpose of the Study:

  • To review marine-derived compounds with antimetastatic properties.
  • To highlight research on cancer cell migration and invasion inhibitors.
  • To provide an updated guide on marine natural products for antimetastatic drug development.

Main Methods:

  • Literature review of scientific research published in the last five years.
  • Analysis of in vitro and in vivo studies on marine compounds.
  • Focus on compounds affecting cancer cell motility and invasion.

Main Results:

  • The marine environment is a rich source of compounds with anti-cancer migration and invasion activity.
  • Various marine-derived products have demonstrated efficacy in preclinical models.
  • These compounds show potential as migrastatics.

Conclusions:

  • Marine natural products represent a promising avenue for developing novel antimetastatic therapies.
  • Further research into these compounds could lead to improved cancer treatments.
  • This review serves as a guide for researchers and pharmaceutical companies.
Keywords:
anti-cancercell invasioncell migrationmarine compoundsmetastasismigrastatics

More Related Videos

Necropsy-based Wild Fish Health Assessment07:57

Necropsy-based Wild Fish Health Assessment

Published on: September 11, 2018

17.4K
Isolation, Fixation and Characterization of Juvenile Gilthead Seabream Head Kidney Leukocytes by Flow Cytometry08:17

Isolation, Fixation and Characterization of Juvenile Gilthead Seabream Head Kidney Leukocytes by Flow Cytometry

Published on: May 9, 2025

468

Related Concept Videos

Migration00:53

Migration

Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters.
8.1K
Osmoregulation in Fishes02:32

Osmoregulation in Fishes

When cells are placed in a hypotonic (low-salt) fluid, they can swell and burst. Meanwhile, cells in a hypertonic solution—with a higher salt concentration—can shrivel and die. How do fish cells avoid these gruesome fates in hypotonic freshwater or hypertonic seawater environments?
50.6K