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A highly regioselective C-5 lithiation of uridine: a simple and general entry to 5-substituted uridines
Nucleic Acids Symposium Series
|January 1, 1986
Abstract:
A highly regioselective C-5 lithiation of uridine was accomplished by using 2',3',5'-tris-O-(tert-butyldimethylsilyl)-uridine and sec-BuLi/TMEDA. The reactions of the C-5 lithiated species with various types of electrophiles and subsequent deprotection provide a simple and general entry to 5-substituted uridines.