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Updated: Sep 21, 2025

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Genetically predicted glucosamine and longevity: A Mendelian randomization study.

So Young Yoon1, Vikram P Narayan2

  • 1System Health & Engineering Major in Graduate School (BK21 Plus Program), Ewha Womans University, Seoul 03760, South Korea; Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, South Korea.

Clinical Nutrition ESPEN
|May 27, 2022
PubMed
Summary
This summary is machine-generated.

Glucosamine supplementation may increase life expectancy, particularly in women. This study found higher genetically predicted glucosamine levels associated with increased maternal longevity, suggesting potential sex-specific benefits.

Keywords:
GlucosamineLifespanLongevityMaternalMendelian randomizationPaternal

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Area of Science:

  • Genetics
  • Longevity Research
  • Nutritional Epidemiology

Background:

  • Glucosamine's impact on health is known, but its effect on lifespan, especially sex-specific differences, remains unclear.
  • Investigating the genetic influence on glucosamine levels and their association with longevity is crucial for understanding its role in aging.

Purpose of the Study:

  • To examine the association between genetically predicted glucosamine levels and parental longevity using a two-sample Mendelian randomization (MR) approach.
  • To determine if glucosamine's effect on lifespan differs between males and females.

Main Methods:

  • Utilized genetic data from the MRC-IEU consortium (461,384 individuals) to identify five genetic variants for glucosamine.
  • Employed inverse-variance weighted (IVW) method to assess the effect of a 1-SD increase in genetically predicted glucosamine on parental longevity (combined, maternal, and paternal age at death).
  • Performed sensitivity analyses to check for pleiotropic effects of the selected genetic variants.

Main Results:

  • A 1-SD increase in genetically predicted glucosamine was linked to higher odds of combined parental age at death (OR=2.64, P=0.01) and maternal age at death (OR=1.73, P=0.03).
  • No significant association was found between genetically predicted glucosamine and paternal age at death (OR=1.32, P=0.27).
  • Sensitivity analyses did not reveal evidence of pleiotropy, supporting the robustness of the findings.

Conclusions:

  • Elevated lifelong glucosamine levels may contribute to increased life expectancy.
  • The positive association between glucosamine and longevity appears to be specific to maternal lifespan.
  • Further research is needed to explore the clinical implications of this sex-specific effect of glucosamine on longevity.