Related Experiment Video

Updated: Sep 21, 2025

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

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A Role for PET/CT in Response Assessment of Malignant Pleural Mesothelioma

Patrick Sandach1, Robert Seifert1, Wolfgang P Fendler1

  • 1Department of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany.

Seminars in Nuclear Medicine
|May 27, 2022
PubMed

Insights

Malignant pleural mesothelioma, a rare cancer, is increasing. This review discusses response assessment criteria like mRECIST, iRECIST, and PERCIST, highlighting FDG-PET/CT

Area of Science:

  • Oncology
  • Radiology
  • Nuclear Medicine

Background:

  • Malignant pleural mesothelioma is a rare cancer with increasing incidence.
  • Its unique growth patterns present diagnostic challenges.
  • Novel immunotherapies are emerging, necessitating standardized response assessment.

Purpose of the Study:

  • To provide an overview of current response assessment criteria for malignant pleural mesothelioma.
  • To discuss the role of imaging in evaluating treatment response.
  • To explore the potential of FDG-PET/CT in managing this cancer.

Main Methods:

  • Review of existing response assessment criteria (mRECIST, iRECIST, PERCIST).
  • Discussion of CT-based criteria limitations.
  • Exploration of FDG-PET/CT's utility in mesothelioma.

Main Results:

  • Current general response criteria are insufficient for mesothelioma.
  • FDG-PET/CT shows potential superiority over CT-based criteria for response assessment.
  • Specific criteria like mRECIST, iRECIST, and PERCIST are relevant but require adaptation.

Conclusions:

  • Standardized, image-derived response criteria are crucial for malignant pleural mesothelioma, especially with new therapies.
  • FDG-PET/CT may offer improved accuracy in assessing treatment response.
  • Further research is needed to validate and refine PET/CT-based criteria for mesothelioma management.

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