Related Experiment Video
Updated: Sep 21, 2025
07:30
Rapid Nanoprobe Signal Enhancement by In Situ Gold Nanoparticle Synthesis
Published on: March 7, 2018
7.7K
Selenium Nanoparticles (SeNPs) Immunomodulation Is More Than Redox Improvement: Serum Proteomics and Transcriptomic
Ivan Fan Xia1,2, Hang-Kin Kong1,3, Margaret M H Wu1,3
1Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Antioxidants (Basel, Switzerland)
|May 28, 2022
Summary
Selenium nanoparticles (SeNPs) modulate immune responses by influencing antioxidant activity and lipid metabolism. Their effect on reactive oxygen species (ROS) shifts during infection, highlighting a link between redox regulation and immunity.
Area of Science:
- Immunology
- Nanotechnology
- Biochemistry
Background:
- Selenium nanoparticles (SeNPs) exhibit bioactivities, including immunomodulation.
- The precise molecular mechanisms of SeNP-induced immunomodulation remain unclear.
Purpose of the Study:
- To elucidate the molecular mechanisms behind SeNP-induced immunomodulation.
- To compare SeNP effects with an antioxidant (Trolox) on immune activity and redox balance.
Main Methods:
- Utilized zebrafish as an immunological model.
- Conducted serum proteomic and tissue transcriptome analyses.
- Assessed immune activity and redox regulation.
Main Results:
- SeNP immunomodulation is linked to antioxidant activity and lipid metabolism.
- SeNPs suppressed reactive oxygen species (ROS) in healthy states but promoted ROS during disease.
- Superoxide dismutase (SOD) and NF-κβ were identified as key regulators in infection.
Conclusions:
- SeNP immunomodulatory effects are associated with redox and lipid metabolism.
- The dual role of SeNPs in ROS regulation during health and disease suggests a complex defense mechanism.
- Immune and redox regulation are closely interconnected, with SeNPs acting as a potential modulator.
